The Killing Mechanism

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Coming To Planet Earth [SunRise Over Planet Earth]

What Is It ?
What Causes It ?
Where Is It Coming From ?


Last Time, We Wrote:


    A Killing Mechanism, Part I and Part II, is coming to Planet Earth, your home and our home.

    It will come from Within and and it will come from Without. There will be a melding of these forces to effect a massive wipeout. The without/within portion will come from Case A and Case B of The Killing Mechanism, Part I, respectively.

    Case A will come from sheer terror, confusion, and chaos, melded with that coming from other countries. This will put extreme stress on the chemistry of the organism that has been under attack for some time now (endocrine disruptors, excess polyunsaturated fats, polluted water and air, over–medication generating reactive oxygen species in excess, etc.) and is prime for a breakdown, such that its normal biological defenses will be overwhelmed. The fittest biochemistries will survive.

    All organisms under attack will have to cope with enhanced Reactive Oxygen Species, excessive Shift bases formed generating Amadori shifts falling into Mallard reactions. Lipid peroxidation will be accelerated. DNA will not be able to do the Dark Repair as continual attacks on it will overcome this mechanism. Tissues will die and not have a chance at repair after a while. The onslaught will be too much for all, except the hardiest of the biochemistries. We are going to witness, throughout all this, "The Survival of The Fittest," and not realize this, until it is all over, with few remaining on Planet Earth years from now.

    Case B will be that coming from within your own bodies. Keep in mind, A and B will meld, increasing the damage. Case A and Case B will become as one.

    The die was cast some 50 years or more ago. Part II of The Killing Mechanism was cast some 26,000 years ago. There is no turning back. We will do as best we can to give what we know that will help one survive. In some cases, nothing can be done.

    The Second portion of The Killing Mechanism, Part II, will come from without. It will come from the stars, and because of the within portion, Case B, Part I, it will reinforce itself and create massive deaths worldwide. The Second Portion of that coming from without will generate a massive kill–off, first. Then, we should, who are left alive, witness a massive die–off—around 2016 – 2020. No one can be sure of the time schedule. It may last a generation or more; or, may happen much faster because of the weakened biochemistries now presented. It was recently given that man is no longer living as long as previously, but he has lost a few years off his lifespan. He is no longer living to 70s plus but now to his later 60s.

    This second portion will be due to the damage done to the genomes of humans and other species. It will take a generation or sooner, to see the what the powerful radiations in the Arm of Orion, enormous electric currents and electromagnetic fields have done to the reproducing organisms, as the Solar System moves through The Galactic Plane.

    There are other denizens "waiting" for something to pass near; still others moving about such that as our Solar System comes close to them, wreaking havoc upon us and the planet.

    It will take time to overcome this damage and develop adaptative chemistries such that in effect, stronger species form from the wreakage. But, in the meantime of such an Event, teratogenic formations, still births, and greatly weakened biochemistries, and altered DNA (whereby the Dark Repair or Excision Repair may not...will not...work effectively), will wreak havoc on species. A massive die–off is inevitable. But...as the die–off occurs, Mother Nature uses adaptative mechanisms to evolve a stronger organism eventually. We can not be sure of any absolute time scale, but a generation or two may pass away during this massive die–off. Some, those strongest biochemically and physically, will survive. Life has a great way of surviving.

    The first part of The Killing Mechanism, Part II, will be a massive kill–off. We give nothing as absolute here and hope this is all wrong, but as you will see from what follows, there is a possibility, slim, maybe, but the possibility still exists.

    We cannot tell you how best to respond in all instances: We do not know, but we do feel, there is a strong possibility that a Slate Wiper is coming, as happened 11,000 to 19,000 years ago on the sparsely populated planet earth at that time. That which is coming now will cause mass exterminations of all the various living forms. From this, the simplest of creatures, the viruses to the bacteria, to the amphibians in all the world's seas, oceans, lakes, rivers, and streams, to the fowls of the air, and on to the higher forms of animal life on planet earth will disappear never to be seen again. From this, a remodeling of species that are the hardiest will take place; some new species will develop generations from here. We can't tell for sure about the time table; nor, the species that change and those that leave the face of the Earth never to grace it again; or, new ones that develop. This we do know: This has happened a number of times in the past.

    From the ashes of the Phoenix, new species will be generated and old species with stronger biochemistries that survive, will be entirely revamped in looks, intelligence, mass, and neural wiring. Life has a great way of surviving, as it did 11,000 – 19,000 years ago when the "Event" happened. And from the old template of species that survived the kill–off and grew, a massive die–off came to those creatures from that "Event," whereby the fittest of creatures survived, and the man of that survival developed a bigger brain case, had better neural wiring, and started producing art, mathematics, poetry, and music, paleontologists inform us.

    This latter portion of the die–off that survives will be "survival of the fittest." This is biochemically important. We see this in molecular biology and biochemistry all the time. "It illustrates the importance of various characteristics that biological molecules play in life." — Biochemistry and Molecular Biology, 3rd. edition, Elliot & Elliot, page 159

    Evolution, under the watchful eye of a prime motivator, developed two characteristics for life to take place and function as well as it does. They are: Polarity (asymmetric charge distribution) and Hydrophobicity (water 'hating'), that are extremely important on a planet such as earth that has water, and then...life.

    Another feature of life is "bonding." Those electrical attractions between and within biomolecules of lipids, proteins, carbohydrates, and DNA. Cellular dysfunction occurs when the "wiring" is forced into wrong configurations or done by outside and/or inside forces, such as Electromagnetic Pulses (EMPs) of varying strengths and frequencies, lipid peroxidations, reactive oxygen species, and so forth. Noncovalent bonds, weak bonds of electrical attraction that do not share equally, are readily broken and reformed, unless an outside or inside force is strong enough to cause a permanent breakage also involving strong covalent bonds.This feature of noncovalent bonds broken and reformed "allows noncovalent bonds to mediate the dynamic interactions that occur among molecules in the cell." —Cell and Molecular Biology: Concepts and Experiments, Gerald Karp, 1st. & 4th. Editions

Note This:

"Without noncovalent bonds, such vital life activities as metabolic reactions, duplication of DNA, and movement of materials within cells could not occur" — Ibid.

    Noncovalent bonds are weak bonds. These bonds are easily disturbed as in the whisking of an egg white, as you'll see in The Killing Mechanism, Section Three. A force, such as that which is coming from the Stars, may disturb them, creating havoc.

Biochemistry and Molecular Biology, by Elliot & Elliot, Third Edition, page 39, writes, concerning weak bonds:

"It is their very weakness that makes them of central importance to life. The essence of almost everything in life involves biological specificity, which depends on one molecule binding to another with such exquisite precision that only the particular molecules designed by evolution to interact do so. To emphasize the point again, the precisely specific binding of molecules one to another is the basis of virtually all biological processes."

An enzyme is specific for one reaction; a hormone for a particular receptor site; proteins recognized and attached to DNA at a particular site because particular proteins control, bind to and recognize a particular stretch of DNA. Antibodies combine with particular antigens. The case goes on and on. How are these interactions molecularly achieved and precise?

Elliot & Elliot write:

"The binding processes in the examples referred to depend on weak bonds and the specificity arises from:
  • The fact that individual bonds are so weak that several must be formed for the attachment to occur; and
  • The weak bonds can form only if the relevant atoms are positioned close enough to each other.
The combination of (1) and (2) means that only molecules shaped to fit their designated partner (s) can bind in this way. The two must be complementary in shape. The relationship can be so precise that, if a single atom is changed in an enzyme substrate, or in the active centre of an enzyme, the interactions do not occur (WebMaster's Emphasis)."

Note:

If something breaks these fragile bonds and keeps them apart; or, they reform in a different fashion, life or health as we have come to know it, may be vastly different, or not exist.

"Binding of substrates to an enzyme must not be so tight that the products of the reaction cannot diffuse away; gene action and reversible gene control demand that interactions are easily reversible," writes Elliot & Elliot.

"In summary, weak bonds permit precise binding between molecules and give the basis for biological specificity. Small numbers of bonds permit easy reversibility of the binding while large numbers can produce stable inter– and intramolecular interactions. The role of weak bonds in biochemistry will be more apparent when we come to the chapters on membranes, protein structure, gene structure, and gene actions" — Ibid.
    Life as we know it, is about to change. For a while, it will be quite rough. Those species that are the strongest physically and/or biochemically, will survive, unless hit by the rocks coming, volcanos erupting, tidal waves three and four miles high, etc. It will get vastly better than anything we can even imagine with this new change coming—we suspect. More of all the immediate above will be explained later.

    The former element, Polarity, appears to be what the universe is made up of, along with antipolarity, which projects into matter and antimatter, among other things.

    Suffice it for now...the violence and senseless killings will now be on the increase. There will be more cop violence against unarmed citizens. This will escalate into more crime against police officers such that some areas will be without policemen because of the uncontrolled violence against them. They will seek other employments. There will be some cities where, if they still have police, will not venture, even with their War Wagons, into the deep ghetto inner cities. These areas will eventually burn. A firestorm will be formed that will spread to the suburbs and outlying areas. The rich will be prime targets. Madness, sheer madness will soon be evident on Planet Earth! Be prepared. We will not be speaking any longer about how to be prepared; only...be prepared.

    This is coming soon as cities go bankrupt. Expect city services to be interrupted, sporadic, or even stopped. There will be laws enacted controlling movement into and out of the metropolises. Movement will be curtailed. Curfews will be set. We saw this during Hurricane Ike and others. Passes will have to be gotten for night shifts to present to the remaining law enforcement when moving about after curfews.

The Killing Mechanism Is Now In Place and Running.


The Killing Mechanism

BackGround


    A number of basic ideas must first be burned into our memory banks. We will discuss as presented; or, later, as necessary to make ideas clearer to understand.

    Some 40 to 60 years ago, we did not have all of the refined foods as we do now; nor was practically everyone on polyunsaturated fats, such as cannola oil, fish oil, etc. These highly fragile oils have peculiar things done to them, unlike saturated fats. The former all undergo lipid peroxidation, the process wherein that fat becomes rancid. Even if you just took vitamins C, E, beta–carotene, and other antioxidants and then quickly ingest fish oil and quickly follow that with more vitamin antioxidants and the mineral selenium, you cannot play catchup and stop the lipid peroxidation from occurring.

    Lipid peroxidation is the process of forming rancid lipids from polyunsaturated fatty acids (PUFAs). There are some web sites that advertise that we all eat rancid fats in one stage or another regularly. They say it does not harm the body. However, you will see that eventually it does as one ages. And with all the endocrine disrupters out there and PUFAs now being ingested, mankind has about reached its limit.

    In just only about 40 to 60 years, we are now reaping—and have been for some time now—what the immediate above are doing to just the American society. Birth rate down, teens mad as hell, violence eruption on teachers, cancer and heart disease still climbing (cancer next year, or this, is to replace heart disease as the number one killer).

    A thing called Reactive Oxygen Species (ROS), is built into the human body. Without it, we can't live, because it is a process that is from the body necessarily using molecular oxygen (oxygen in the atmosphere). Programmed death is built into the body! Yet, we can slow it down (provided we control infections) doing certain things and being aware of this function, that can't be avoided. Oxygen is a "Sword of Damocles." It is a two–edged sword. It gives life and it takes life. It is very toxic.

    Oxygen appeared on the Earth about 2.2 billion years ago. Cyanobacteria, in making food from the chemical soup at that time, spewed out its waste product, oxygen, for billions of years. This filled up the atmosphere with it. Other organisms developed and evolved and learned to use oxygen. Many species probably died, but the fittest survived. They learned how to get around its toxicity and grew and multiplied. It eventually took them out, but the species survived and continued to evolve and multiply. This same adaptation is about to occur with all species again, but in a short span of time, we feel. The templates and biochemistries are already here—they don't need to be created this time; however, we feel some definite remodelling will occur, resulting in a better species and some to many new species created.

    We will discuss, in addition to Lipid Peroxidation and ROS, Spin Restrictions–thermodynamic barriers to spin inversion (this is coming!), Bond Scission, or Bond–breaking. All figure in The Killing Mechanism, whether Part I with its Cases A/B, and Part II.

    We ask you to endure with us for attempting to make this simple whereby it can be understood. Wherein such simplicity is involved, unavoidably, some scientific misunderstanding can be introduced into the the subject matter. Your WebMasters also have a large number of science people studying this site to stay abreast of what is happening in our society. Some of this material is for them too. The WebMasters could write a textbook on this matter. This is not our objective in this instance. We hope it has not been over-simplified. Our job in this matter is to present the material such that one can come away from here knowing what is happening out there when it starts in full view of everyone and perhaps, have some means of surviving in relatively good health and mind, and help them avoid panicking. Being forewarned is being forearmed.

    Section Two:


    Predictions
    2009


    Writing in the January 2009, issue of U.S. & World Early Warning Report, Richard Maybury points out what's facing Obama after he takes office, and states that Obama must place:
    "The blame for the economic mess squarely where it belongs, on the Federal Reserve's 94 years of inflating the money supply.

    If Obama does not do this, then the blame will be placed on him. Among the many terrible results will be that every bigot in the country will be shouting, We told you so!, and race relations will be set back a half–century."

    Various newsletter writers over the years have said that the main reason that J.F. Kennedy was assassinated was because big business, chiefly the big bankers, did not like him. This stemmed from the fact that he and his brother, Robert Kennedy, were formulating plans to do away with the Federal Reserve.

    It is unfortunate that Obama inherited such a Shit Sandwich, coined by popular freelance writer and author, James Howard Kunstler. There may be several attempts on his life if things don't improve within the year, and we do not feel they will. Furthermore, we feel the attempts will primarily come from Within, rather than from Without, his party, though made to look like the latter.

    Richard Maybury also feels you need to spend some money on security. "Make a hobby of emergency preparedness," he writes. also:

    "Your neighbors' complacency is your best protection. As long as you are a less attractive target than they are, the crooks are not likely to bother you."

    You WebMasters add: "Don't count on it!"


    Maybury writes in the March 2009, issue of U.S. & World Early Warning Report:

    "A small prediction: as the economic crisis worsens, Americans will rediscover Ronald Regan's words:

    'Government isn't the solution, it's the problem.'

    "State and local officials will open their eyes to what's being done to us, and will arrive at the question, why play this circular game? Why not just eliminate the middle–man and keep the wealth for ourselves?

    "The federal government will begin to starve. Washington will finally be seen for what it is — the country's most dangerous enemy — and we will be on the road to revolution."

    ...and he writes this regarding Obama:

    "Only one person, Obama, has the influence to manipulate the velocity of the US dollar.

    "All his life he was taught that the government has the knowledge, honor and wisdom to control the economy and make things better. At his inauguration, he signed on to be emperor of the world, and now he is in the process of learning that the emperor has no clothes.

    "He must be dejected. At some point, he could become despondent; he might even break down and start crying right in fron of the cameras.

    Velocity (Editor's Note: the speed in which money movement in a society changes hands) would freeze solid.

    "The strain on this man is unimaginable. So, again, if you do get back into non–dollar assets now, don't get in deeply. For a full commitment, I plan to wait until I believe velocity has turned and the flight from the dollar is becoming so strong that nothing Obama says or does can reverse it."

    Subscription To U.S. & World Early Warning Report®

    Just 44 days into the job, and President Obama is going gray. The stress of running the country is onerous on him:

    Before Being President

    [Obama 44 Days Before Office]


    44 Days After Becoming President

    [Obama 44 Days After Becoming President]

    Folks! Even if you prepared, the Stress and Strain will be onerous on you. If you did not prepare, it will be inordinate!


  • Reactive Oxygen Species (ROS)—Because oxygen is a free radical (Gilbert, 1981; Halliwell and Gutteridge, 2006), it has the tendency to form highly reactive oxygen species which can generate free radicals causing chain reactions and causing cellular component damage:

    Reactive Oxygen Species

    Superoxide Anion
    O2-
    Produced by the electron transport chain and at other sites. Generates other reactive oxygen species but cannot diffuse far from the site of origin.
    Hydrogen Peroxide
    H2O2
    Not a free radical, but can generate free radicals by reaction with a transition metal (e.g., iron: Fe2+). Can diffuse into and through cell membranes.
    Hydroxyl Radical
    OH.
    The most reactive species in attacking biological molecules. Produced by water in the presence of iron (Fe2+).
    Organic Radicals
    R.
    An organic free radical produced from RH (Polyunsaturated Lipid) by OH. attack. RH can be the carbon of a double bond in a fatty acid (resulting in -C.=C-) or RSH (organic thiol) (resulting in R-S.)
    Organic Peroxide         Radical
    RCOO.
    An organic peroxide radical, such as occurs during lipid degradation.
    Hypochlorous Acid
    HOCl
    Produced in bacteria during the respiratory burst to destroy invading organisms.
    Singlet Oxygen
    O↑↓
    Oxygen with antiparallel spins. Produced at high oxygen tensions from the absorption of energy. Decays with the release of light.


    Oxygen is a two–edged sword. It's necessary for life. In order to use molecular oxygen, the human body had to evolve with this gas already here and had to learn how to use it and avoid its deadly effects. There may have been numerous times, if you and I were watching human evolution, that we thought human organisms would not make it.

    But, God had other plans. Mitochondria are now most definitely thought to have been a microbe using oxygen first and then somehow conjoined with other cells, evolving into what are now higher animals. Without them, we could not have used oxygen effectively. It was a 'marriage' made in heaven.

    Instead of making the higher organisms sick, they gave it energy, fueling the organism's requirement for growth, multiplying, and repair. In return, the organism gave food and greater protection to the bacteria. The symbiosis of the two probably took place 250 million to 150 million years ago in an epoch before the dinosaurs and evolved through their reign. A melding eventually took place and symbiosis faded as they became one.

    Evidence shows evolution probably used a trial and error situation in that during this first period, "a bacterium took up residence inside the body of an insect. The bacterium may have been friend, foe, or neither to its host." But this was later resolved after eons of time and friendship was established. — Science News, 'A More Perfect Union,' May 19, 2001. Karp, writing in his fourth edition, says of this matter:

    "Mitochondria have evolved from an ancient aerobic bacterium that took up residence inside the cytoplasm of an anaerobic host cell."

    The bacteria evidently learn through the trial and error of evolution. Otherwise, as soon as an organism begins using oxygen, the organism, being a collection of organic molecules, would immediately go into spontaneous combustion and vaporize. If the latter problem had already been solved by the planetary forces in its early beginning, and this spontaneous combustion was not a problem because of the spin restriction applied to oxygen, then later, or simultaneously, the friendship was established at the same time or shortly—in geologic time scales—thereafter, and oxygen was controlled and not immediately toxic as the spontaneous combustion problem was solved at the same time of oxygen's toxicity. This was a huge problem. But not so big that the Mind of God could not work it out.

    Karp in his first publication of Cell and Molecular Biology: Concepts and Experiments, says:

    "The fact that mitochondria are similar in size to bacteria is more than coincidental, since a body of evidence suggests that these organelles have evolved from bacteria that lived symbiotically within other cells. In some cells, such as those of early embryos, mitochondria are almost spherical in shape, whereas in others, such as fibroblasts, they are elongate, threadlike structures.

    "Consistent with their central role in making chemical energy available to a cell, mitochondrial size, number, and intracellular location vary from one type of cell to another. An average mammalian liver cell contains about 1500 mitochondria, corresponding to 15 to 20 percent of the cell's volume. Mitochrondria are even more numerous in muscle cells, which require large amounts of ATP to fuel their contraction. Mitochondria are often associated with fatty acid–containing oil droplets from which they derive raw materials to be oxidized."

    Now, here's the interesting rub, when you see a person with lots of energy, that is one definite item it used to be thought they inherited only from their mother, unless something goes awry. You inherited the genes for the power plants, the mitochondria, from a mother's genome and not the father's.

    You mothers–to–be: Don't smoke, cut out the polyunsaturated fats except that you receive in corn, flax seeds, nuts, etc. Do not poison your genetic materal such that it is altered and not in full bloom to transfer to your offspring the mitochondria in full focus. Do not smoke, do drugs, and so forth. Live a chaste life and hope and pray for the best, because there are so many endocrine disrupters out there now, including that in fish, water, and foods—yes, even the so–called "organic" foods.

    The Associated Press, August 22, 2002, writes in, 'Study of man's cellular makeup renders surprise':

    "Cells employ mitochondria — microscopic creatures captured eons ago — to extract energy from food. Mitochondria have their own genes, separate from the usual human blueprints, and scientists long believed that only mothers passed them on to the next generation.

    "Danish scientists have documented the first known exception to the rule, a man whose muscle cells contain mitochondria that came mainly from his father," according to Marianne Schwartz, geneticist at Copenhagen University Hospital. It could have been a mutation in the genetic materia for the mitochondria from the mother that forced paternal derivation. So prospective fathers need to follow the same proscriptions as women for progeny in the future.

    Frank Ryan, M.D., in Virus X, writes:

    "Lynn Margulis, a biologist at Amherst College ... believes that through symbiosis radically different life forms combine to accomplish more than either could separately."

    Dr. Ryan continues...

    "The mitochrondria that provide animal cells with oxygen–derived energy were once independent bacteria that were engulfed by the primal cells that later evolved into animals. This is almost certainly the explanation for a curious paradox. Mitochondria have their own hereditary DNA which needs to divide by its own private little binary fission every time the cell itself divides. And plant cells too have their astonishing equivalent, chloroplasts, which provide them with the ability to photosynthesize."

    Everywhere you look, one sees God's handiwork in his creation. Symbiosis is present in "holobionts," of fungi and algae. Why did He do it this way? As the great astrophysicist, Stephen Hawking, says in his writings concerning a different topic, "To know the answer to that would be to know the mind of God."

    For instance, the universe is full of puzzling handiwork. Hawking's A Brief History of Time speaks of Roger Penrose of Oxford University and theoretical mathematician. Professor Hawking and Roger Penrose proved "that in the beginning of time would have been a point of infinite density and infinite curvature of space–time." Laplace, the great French Mathematician, "theorized that God chose how the universe began and what laws it would obey, but did not intervene thereafter," writes Hawking. The following question is often brought up by "philosophers, scientists, and just ordinary people:

    "Why it is that we and the universe exist? If we find the answer to that, it would be the ultimate triumph of human reason — for then we would know the mind of God."
    Virus X also points out:

    "The cell bodies of coral, an animal, embrace in their living protoplasm the bodies of algae, which are plants. The algae make sugars and starches through photosynthesis that provide nourishment for the coral, while the coral provides a shelter and supplies of otherwise scarce phosphate and nitrogen essential to the algae. Bacteria fix nitrogen around the roots of leguminous plants; other bacteria fix sulphur or methane in symbiotic partnerships with marine invertebrates"

    Symbiosis is everywhere and it was probably mostly wiped out 11,000 to 19,000 years ago in a mass extinction, with new forms of life coming into existance by virture of "Survival of the Fittest." Everything on this planet lives in a symbiotic relationship which may soon be disrupted.

    Now, here's the difficulty presented:

    "All of the great cycles of life on earth are symbiotic in a more holistic sense. So green plants on land and in water, produce the oxygen that animals, including humans, breathe. Animals, in their turn, produce the carbon dioxide the plants need to manufacture carbohydrates. The humble bacteria that teem in soil recycle elements such as carbon and nitrogen, derived from the complex chemicals and proteins of animals and plants, and enable the new generation of plants to reutilize them in their growth. How extraordinary it is to realize that if these humble microbes that live in the soil were to die off, all of the higher life on earth, including humanity, would become extinct! The harder one looks, the more important the role of symbiosis in all of the great cycles and balances that play such a vital role in life on earth."

    Think about this for a second. All life would stop if microbes were sterilized off the earth. Hold all the thoughts from above and see them as one thought. With The Killing Mechanism, Part II coming to this planet, we may just witness a mass extermination of animal and plant forms. This has happened in the past, and in some mysterious way life was remodeled, reformulated, and one might say, recreated. Life has a great way of surviving. But, it's gonna be greatly reduced!

    Destroy any one of the symbionts from above; you have altered the Master Plan. For example, getting rid of one of the symbionts that are necessary to grow food, and mass extermination follows. Now...let's investigate this wonderful two–edged sword, oxygen, and see why it is magnificient for us...and at the same time, destroys us.

    • Oxidative Stress — This occurs when ROS production exceeds the cells' removal capacity. "When ROS are produced faster than they can be removed by the cellular defenses, the cellular mechanisms" become stressed by reactive oxygen species:

      The oxygen we consume from the air, molecular oxygen, is fed throughout the body, being used in several systems. The Respiratory Cellular System (also known as the Electron Transport Chain), oxygen will accept electrons from NADH. Many of you reading this have found that taking such a substance from your natural food store has increased your energy, noticed recovery from infections and illnesses quicker, and overall feeling better. The body also gets the NAD radical from niacin—the B vitamin that flushes one. Oxygen also accepts electrons from FAD(2H). The Electron Transport Chain is where part of your oxygen goes. The remainder is used by Oxidases and Oxygenases in the cells of the body. The former are enzymes (protein in nature) that reduce oxygen and cause it to gain electrons, and be converted to water or hydrogen peroxide. The latter, Oxygenases, are enzymes that incorporate molecular oxygen from the atmosphere directly into the molecules being oxidized.

      Food "burning" in our bodies is a very dangerous process, if the electron transport system was not in place. Just remember these foods are organic molecules known as substrates—the thing that oxygen is used in by means of enzymes bringing the two together and causing oxidation, one step at time. This is important! Without such enzymes, an explosive nature exists. Without these enzymes, energy is released all at once. This is an important point to grasp for The Killing Mechanism, Part II.

      These oxidases/oxygenases are not coupled to the production of ATP. Remember, ATP is the energy currency of the body. Without that, life as we know it does not exist. Regardless, these latter oxidations are necessary for the drug detoxifications, the catabolism (breakdown) of amino acids, and steroid hormone synthesis.

      Now, we come to a very important point. Because of oxygen's electronic structure, physiological oxidation reactions (generation of energy and detoxifications), those reactions of a toxicological nature (detoxifications) occur via single electron transfers. The oxygen in the atmosphere, molecular oxygen, that which we breathe, if one takes a match; strikes it, and it bursts into flames; then, if one holds a material such as paper, organic molecules, it bursts suddenly into flames when the heat of combustion is reached.

      Let's say this another way: When the oxygen of the air has enough energy applied to it, as in a match, in the presence of an organic molecule, spontaneous combustion occurs, as in gasoline (hydrocarbon—organic molecules) vapors that are not dispersed quickly enough, but that float in a cloud. Ask any war veteran if he has seen an explosion of vapors rising and expanding in all directions, creating a roiling ball of fire.

      You should now begin to see what keeps the body from spontaneous combustion in a sea of oxygen around us as we use oxygen in our bodies. As given above, this is a simple process involved in the electron transport system utilizing enzymes. In the case of detoxifications, or anywhere else oxygen is used in the body, when it comes into contact with biomolecules' (organic molecules) enzymes, especially in the respiratory system, the enzymes reduce oxygen one step at a time, otherwise, you are going to see the most rapid spontaneous combustion ever.

      You will probably see something analogous to a sodium flash in a chemistry laboratory experiment performed by the professor when he is using sodium to demonstrate why one should be cautious with such an item when in the presence of oxygen and moisture. Sodium metal spontaneously goes into combustion. It can be awesome when one witnesses a phosphorous explosion in combat. Almost a blinding flash of light as anything in the immediate vicinity is vaporized.

      The reason for this is that dioxygen (molecular oxygen) has two electrons that are unpaired. It is a free radical actually, but not referred to as such. Its electrons spin parallel (two unpaired electrons with a parallel spin) and are antibonding because of this configuration. This antibonding parallel spin prevents organic molecules (molecules containing carbon) such as those forming humans and other forms of life, from igniting spontaneously in an atmosphere of oxygen.

      What happens is that energy is transferred slowly from a carbon to hydrogen molecule (organic molecules), one electron step at a time from an organic molecule to oxygen by means of enzymes, these oxidations of foodstuffs or transferring of electrons within a human's electron transport chain, occur smoothly.The enzymes doing this use transition metals, such as iron, Fe (II), and copper, Cu (I) in cytochrome oxidase. Over eons of time, cytochrome oxidase learned how to do this by overcoming spin restrictions. This is a quantum mechanics thing. We will explain without all the math and do so in a simplified manner.

      Oxygen, as you have been reading, is toxic and necessary to have life as we know it. This two–edged sword is a paradox. This paradox favors dioxygen (molecular oxygen) in a step wise reduction in single electron movements producing carbon dioxide, water, and energy, or rather the energy currency of the cell, ATP. By having the oxygen molecule, which can accept a total of 4 electrons to be reduced to 2 molecules of water, can be reduced one electron at a time, with two electrons moving down the electron transport gradient at a time.

      Karp says it this way in the Fourth Edition of Cell and Molecular Biology: Concepts and Experiments:

      "The carriers of the electron–transport chain are arranged in order of increasingly positive redox potential. Each carrier is reduced (gains electrons) by the gain of electrons from the preceding carrier in the chain and is subsequently oxidized by the loss of electrons to the carrier following it. Thus, electrons are passed from one carrier to the next, losing energy as they move 'downhill' along the chain. The final acceptor of this electron 'bucket brigade' is O2, which accepts the energy–depleted electrons and is reduced to water."

      "The stepwise reduction slows the direct combination of oxygen with organic compounds (spontaneous combustion) and allows the cell to oxidize fuels through the action of dehydrogenases, which eventually couple the reducing power of oxygen to ATP generation in the electron transport chain"— Basic Medical Biochemistry: A Clinical Approach, Marks & Marks, Smith.

      The paradox is this: Because of the structure of oxygen, reactive oxygen species are generated which are capable of, and do cause, cell injury as we age. However, because of the tremendous PUFAs, normal cellular defenses are continually overwhelmed and dysfunction comes on sooner; then, disease; then, death. We have been set–up for The Killing Mechanism, Part I and Part II, by overabundance of drugs, PUFAs, endocrine disrupters, pollution of waters, food, and the air we breathe. The reactive oxygen species (ROS) is a built–in mechanism that is spewed off from this pecularity of oxygen. We will investigate this closer soon. But for now, let us continue in the presentation of oxygen and its necessity for life; how it can cause cellular dysfunction, and why we do not burst into spontaneous combustion just breathing the atmospheric oxygen around us.

      Cellular injury, ROS, and phagocytosis (defense against foreign objects, mainly microbes) use oxygen in these events, such as ischemia (a condition generated by a loss of supply of oxygen which then also decreases ATP production), and in other conditions in the body that cause more ROS generation from oxygen.

      Oxygen has, as given above, 2 unpaired electrons in different orbits that spin parallel to one another. This is an antibonding effect for those electrons. This configuration is most stable (ground state) for oxygen. It is this form that exists around us in nature—the air we breathe. Here, oxygen is a potent oxidizing agent. It is known as a strong oxidant. It will receive electrons from other molecules.

      But, the biomolecules (substrates—that which is acted upon), lipids, fats, DNA, carbohydrates, and any organic (contains carbon) molecules have 2 paired electrons with antiparallel spins.

      For oxygen to accept a pair of electrons from organic molecules, either one of the oxygen molecules; or, one of the incoming electrons from the substrate (organic molecules) must spin invert. In other words, oxygen and the biomolecules (or substrate) must be parallel to one another in their spins or antiparallel. They become one. They have similar spins in the parallel or antiparallel state. But, there is a Spin Restriction such that "there is a large thermodynamic barrier to spin inversion, and it would have to occur through a multistep process with a high activation energy. The kinetic barrier resulting from this spin restriction slows down direct oxidation of carbon to hydrogen bonds in organic molecules and deters the spontaneous combustion of fuels." — Ibid

      This spin restriction forces oxygen to accept electrons in a step–wise fashion, one electron at a time. And, this helps explain why oxygen reacts sluggishly with organic molecules or non–radicals. On the other hand, oxygen reacts quite expediently with other radicals by transferring single electrons.

      Consider this: You have a book that is in pristine condition; that is, the pages are not yellow. Fifteen to thirty years from now you look again at that book and the pages are yellowing and some are dark yellow brown. Years later, many of those pages have disintegrated. What is happening is that the book pages are oxidizing, they are burning very slowly. The oxygen in the air is reacting slowly with the paper and the yellow and brown pages are in a slow burn. But, if you strike a match to the pages, this is bringing a high enough temperature increase whereby it bursts into flames. You added energy in the form of higher temperature.

      If a human body, or a plant, or any organic molecules have high temperatures brought near them, homolytic bond fission occurs and oxygen reacts with gusto and leaps onto the radicals formed from the high temperatures, and combustion is started — Gilbert, 1981; Halliwell and Gutteridge, 2006. Most molecules in living things are non radicals, but, apply enough energy and things change; thermodynamic barriers to spin inversions are overcome and spontaneous combustion occurs.

      As we move more into the Arm of Orion in the Milky Way Galaxy, enormous energies in the form of huge electric currents and powerful electromagnetic fields are present that can serve as the energy source if we broach them to cause:

      • Spin inversion (and you know what this means from the above paragraphs); or,

      • High temperatures to overcome the single electron step–wise reduction; or,

      We are going to see things we have never seen before! Many are going to perish from this...but, this is dependent upon the Stars and what is in them as we pass near these heavenly bodies.

      This does not happen with oxygen in our bodies or the oxygen on the outside of our persons because of the Spin Restrictions. But...if they are overcome by some awesome means, then this will happen.

      Just now, the Sun's Heliosphere, the Sun's protective bubble is shrinking, The London Daily Telegraph reports December 1, 2008, London, England, UK:

      "Dr Nathan Schwadron, co-investigator on the IBEX mission at Boston University, said: 'The interstellar medium, which is part of the galaxy as a whole, is actually quite a harsh environment. There is a very high energy galactic radiation that is dangerous to living things.

      "'Around 90 per cent of the galactic cosmic radiation is deflected by our heliosphere, so the boundary protects us from this harsh galactic environment.'

      "The heliosphere is created by the solar wind, a combination of electrically charged particles and magnetic fields that emanate a more than a million miles an hour from the sun, meet the intergalactic gas that fills the gaps in space between solar systems."

      Keep this in mind when we write more of The Killing Mechanism, Part II. We are left more vulnerable to what is coming from the Stars if the heliosphere goes. We still have to deal with The Galactic Plane!

      .... And read about [A Fierce Solar Storm] 90 Seconds From Hell, and what it could do to Planet Earth.... but first read the following from McAlvaney and ponder it in your head as you read the hot link:

      "In the 1970s government statisticians calculated that if all electricity were cut off, 30 % of the population would be dead within a month. Within a year, 80 % would be dead. And that was back in the 1970s ... now it's worse!"– The McAlvaney Intelligence Advisor, August 1999.


      Basic Medical Biochemistry writes:

      "One–electron reductions of oxygen are not subject to the kinetic barrier imposed by spin restriction, and occur in the presence of one–electron donors. The Oxygen molecule, which can accept a total of 4 electrons to be reduced to 2 molecules of water, can be reduced one electron at a time. However, the first step, the formation of superoxide, is not thermodynamically favorable and requires a moderately strong reducing agent which can donate single electrons.

      "Enzymes that catalyze the reduction of oxygen, such as cytochrome oxidase in the electron transport chain must have mechanisms that get around the spin restriction and/or the energy requirement of the first electron transfer. In addition, they must have active sites that prevent the interaction of these partially reduced forms (including hydrogen peroxide, hydroxyl radical, organic radicals, organic peroxide radicals, hypochlorous acid, and singlet oxygen) of oxygen with other cellular components."

      Note:

      Cytochrome Oxidase is "An enzyme complex comprising the terminal two cytochromes (cytochromes a and a3) of the respiratory chain in the mitochondria. It is responsible for the reduction of oxygen, receiving two electrons from cytochrome c (which precedes it in the chain) and combining them with two hydrogen ions and an oxygen atom to form water" — Oxford Dictionary of Biology.

      The main point to be recognized is that if anything happens to any one of the enzymes in the electron transport chain, energy goes down. The organism stumbles...goes down...as a drunken individual. And can't get up again, in this case, if the enzyme is not restored. The body biochemically cannot build and repair efficiently when energy is down; nor can motor (muscular) movement occur effectively when the energy currency of the body (ATP) is down.

      The Stress that we are going to witness soon now will most definitely do the following, among other things:

      Stress decreases thyroid activity. Decreased thyroid activity decreases cytochrome oxidase, which generates into tiredness and lethargy. If stress is sustained, building and repair biochemically goes down...disease ensues...death eventually results sooner...or later.

      Stress increases Cortisol (stress hormone) production, which lowers or decreases cytochrome oxidase activity (Simon, et al., 1998).

      Thus, we have stress lowering thyroid activity, which extrapolates to decreased cytochrome oxidase activity, and stress increasing cortisol activity, which also lowers cytochrome oxidase.

      Dr. Ray Peat Writes in Ray Peat's Newsletter, November 2008, page 2:

      "With decreased activity of respiratory enzyme, the brain will be in a relatively reduced state, with a higher ratio of NADH (a reduced substance that transfers electrons from the glycolysis sequence to the electron transport chain) to NAD (oxidized substance) (Pasichna, et al.m 2004; Steen, et al., 1987).

      "Cells are more susceptible to free radical damage in the reduced state, and this contributes to lipid peroxide."

      Note:

      NADH is produced also "in the Krebs cycle and in conversion of pyruvic acid to acetyl CoA" — An Introduction to Chemistry for Biology Students, Seventh Edition, Sackheim, George I.

      Dr. Peat Continues:

      "In MS, lipid peroxidation, indicating oxidative stress, is increased (Toshniwal and Zarling, 1992)."

      Your editor and Dr. Brocato believes, and facts prove this out, that not only is Multiple Sclerosis increasing, but, it will explode upon the scene with a vengence as the stress goes up. Lipid peroxidation is caused by peroxidation of unsaturated fatty acids, especially the omega 3s, including fish oils. What is the American population told to eat more of?

      When peroxidation of polyunsaturated fatty acids (PUFAs) occurs, one of the end products formed is isoprostanes, produced from those PUFAs as oxidative stress occurs. These isoprostanes are increased in the cerebrospinal fluid of the Multiple Sclerosis patients.

      This fluid bathes the brain and spinal column. The isoprostanes attack the myelin sheath of nerves contained therein. This damage is now recognized as foreign material and it is the job of certain cells to remove it. The medical profession, for the most part, still does not allow this thought in its culture. Hence, physicians are still using "'genes' and the 'immune system,' with 'autoimmunity' possibly triggered by a previous viral infection, such as measels" — Ibid.

      It appears that vitamin D, pregnenolone, progesterone, thyroid hormone, and no PUFAs, may help an MS patient go into remission. It may keep one from developing MS.


      Stress And Electron Transporters


      Stress also produces nitric oxide, which first counters the stress. It does this by causing the blood vessels to open and more blood is delivered to tissues. Nitric oxide also does something else: It inhibits the respiratory enzyme, cytochrome oxidase, the terminal carrier for electrons in the electron transport chain, to hand off electrons to oxygen to form water. In this process, the energy currency of the body, ATP, is generated, along with, as given, water and carbon dioxide.

      When cytochrome oxidase is inhibited in function, oxygen needs are reduced. The major production of energy is shifted to glycolysis. This forms lactic acid instead of carbon dioxide. This process happens in the body when oxygen becomes scarce.

      This action moves in raising the pH of cells. When this occurs, we have a higher (spoken above) ratio of NADH to NAD. As given above, as this ratio is generated and sustained, we have a situation in which cells are more susceptible to damage from free radicals. This extrapolates to peroxidation of polyunsaturated fatty acids. When this happens, cells leak. This is occurring through the organism ingesting fatty acids as such, and more in those organisms ingesting prodigious amounts of the omega 3 fats.

      But, other things happen when this ratio of NADH/NAD is elevated. The respiratory enzyme is temporary elevated and can become permanent. The dilated blood vessels then become even more permeable. When this occurs, molecules leak from the plasma to tissues. Blood outside of its domain is toxic to tissues.

      Still, to make matters worse, the lactate generated also contributes to vascular permeability. And the situation gets even worse as the lactate itself facilitates permeability of the blood vessels. Also, lactate interferes with cytochrome oxidase, the respiratory enzyme, production.

      Dr. Ray Peat, PhD., writes in his November 2008, newsletter:

      "Many stress-related factors besides NO (nitric oxide) contribute to vascular leakiness, including cortisol, estrogen, prolactin, histamine, serotonin, carbon monoxide, polyunsaturated fatty acids, prostaglandins, and probably endogenous opiates, such as beta-endorphins. During hypoxia (low oxygen) beta-endorphin also suppresses respiration (Xu, et al., 199), and lowers the metabolic rate (Lin and Su, 1979). "Stress can cause vascular leakiness in any organ, and can disrupt the blood brain barrier, causing leakiness into the brain."

      From what you are reading, you can see that the inordinate amount of stress coming from within and from without is going to cause enormous problems. Some to many of the world's population will go down. When this is all over, early Church Saints predicted from 2/3s to 3/4s of the world's population will be reduced. In fact, we'll have trouble finding one another.

      Dr. Peat further writes in the November 2008, newsletter:

      "Fibrin and fibrinogen, the blood clotting proteins, and their breakdown products, and other proteins, fats, and even red blood cells, can pass from the blood into the brain (Esposito, et al., 2001, 2002; Theoharides, et al., 2007). The entry of fibrin and related proteins into the brain precedes the entry of cells (Floris, et al., 2003)."

      We are going to see more Multiple Sclerosis, and in MS an increased blood viscosity (thickness) will generate blood clots rapidly, with a lessening of the ability to remove those clots.

      Your WebMaster's question, with all the sexual enhancing drugs in the environment, the increased sales of nitric oxide stimulators, and medications to enhance lowering of blood pressure and opening the penile vascular bed, whether the world may be on the eve of destruction from just these modalities alone, which it has never witnessed before.

      Comment:

      Dr. Brocato wonders how many parents may have unwittingly programmed their infants and children for The Killing Mechanism by feeding them soya (estrogenic actions).

      And this is coupled with the fact of increased consumption of polyunsaturated fats in that age group, the same as with all other age groups.

      We have been programmed for death! We have been Picnicking on The Banks of Hell and are now slipping into the abyss.


      Endotoxin from bacteria in the gut, also increases the production of cortisol, among other things. And with all the unsaturated fats we are told to ingest, leaky gut occurs, increasing the absorption of endotoxin into the bloodstream.

      Dr. Mary G. Enig, Ph.D, world–class lipids chemist, writes in the Spring 2007, issue of Wise Traditions, pp. 56 – 57:

      "As far as cancer prevention is concerned, EFAs represent a two–edge sword. Small numbers in the cell membrane do allow oxygen to enter the cell, but if the cell membrane contains too many unsaturated fatty acids, the cell becomes 'leaky' with all sorts of compounds going into and out of the cell when they are not supposed to.

      EFAs can easily become rancid, meaning that free radicals develop during processing, cooking and exposure to air, causing uncontrolled reactions in the body. And finally...a surfeit of EFAs lowers immunity. For these reasons, EFAs can contribute to cancer, even though they also play a role in preventing cancer."

      It should be readily understood and seen that the human race is now in serious trouble. A WipeOut is on the horizon. Reconsider The Killing Mechanism, Part One with A & B parts and what humans have been eating, drinking, and breathing, a programmed dysfunction is staring humanity in the face. Many are not going to make it through this first part.

      The unknown in the Second Part, also involving A & B coming, from the Stars and in and of itself can do a massive kill–off. And this coupling to B, with Spin Restrictions of organisms possibly changing, the over ingestion of PUFAs, and the inordinate amount of ROSs formed in both Part I and Part II, creates a condition in place for a massive die–off, as biochemistries have been set–up for a WipeOut. Part A of the Second Part of that from the Stars in and of itself can create a WipeOut.

      Those that survive The Galactic Plane's problems wipeout (radiations, EMFs, enormous electric currents, tidal waves, volcanoes, rocks falling, etc.) will generate in their offspring chemistries that will succumb eventually (the die–off), the B Portion of the Second Part. This will be coupled with weakened biochemistries of various organisms that survive the initial attack from the stars, and they too will succumb. Then, throughout all this, those fittest biochemistries that make it through The Killing Mechanism: Part I, A & B; Part II, A & B, will be "Survival of The Fittest."

      Remember, Part I, A is all the confusion, chaos, strife, and lack of food and energy products. Part B of I is the inordinate amount of stress, coupled with Part A, will cause dysfunction, disease, and death. Part II of The Killing Mechanism has an A and B part also.

      Let's take the B part first. The oxidative stress will be more than an organism can handle, coupled with Part B of Part I. And this reflects back to the coupling of these B's with the A of Part I. But still, there's more: That which is coming from the stars, conjoined with the two B's (Part I B and Part II B) will create ultimate havoc on the biochemistries of any organism that is not the fittest biochemically. We will not know who these biochemistries of the fittest are until it is all over. Of course, a spherule, or a rock, or a volcano, or a giant flood, could get one of the fittest, and he, too, won't survive. See all this we have given, The Killing Mechanism, Part I (A & B) and Part II, with A & B as one Single–Instant generalization.

    • Cellular Defenses:

      When oxidative stress is present, cellular defenses go into action quelling the response from reactive oxidative species (ROS). Since there is a continuous generation of ROS from microsecond to microsecond in all the 100 plus trillion cells of the body, cellular defenses are constantly on the move. A number of mechanisms have developed to null and void the ROS reactions, such as Superoxide dismutase (SOD).

      This removes (see Chart Above: Reactive Oxygen Species) the superoxide anion free radical. Catalase, which is ubiquitous throughout the body, except the brain, and does not seem to diminish much throughout the aging process, scavanges hydrogen peroxide, and glutathione peroxidase removes lipid peroxides (aka lipid hydroperoxides), LOOH.

      Not generally appreciated is that "Since brain has little catalase, this latter enzyme (glutathione peroxidase) possibly is the main one for protection against H2O2 in that organ" — Biochemistry and Molecular Biology, Elliott & Elliott, Third Edition.

      You can't go out and buy glutathione peroxidase. If you could, it would be digested by the digestive juices. But, you can get glutathione. Coupled with the proteins in your diet, and if you ingest a little selenium, your body does have at least the raw products to make it if the body is working well enough.

      Glutathione can be purchased at natural food stores and is found in cruciferous vegetables, which include cauliflower, broccoli, brussels sprouts, kale, and cabbage. It is also found in horseradish. However, horseradish may interfere with certain tests your physician may have performed on occasion. Thus, if tests are to be run, be off the horseradish for several days to a week. But, these are the vegetables you most definitely want to grow, in addition to others, when food becomes scarce. Plan ahead and have heirloom seeds stored for these vegetables and others.

      However, there is "leakage" of ROS from cellular compartments, where these ROS products are maintained and broken down. This leakage is increased with consumption of PUFAs, and if these deadly components (highly reactive oxygen substances) are not scavenged, they can do damage to surrounding cells and membranes.

      If the cellular compartments become damaged, say from leakage, then a pulse of ROS has free reign to do damage to organelles' membranes, such as mitochondria (cell's powerhouse where ATP is generated); or, to DNA membrane, wreaking havoc on the genome. They are no longer under the "watchful eye" of catalase and other enzymes that scavenge these free radicals. But the damage is quickly contained by other chemicals, vitamins, and the mineral selenium complexed to proteins, which is necessary for the completion of glutathione peroxidase. These peroxidases are selenoproteins found essentially in all tissues. Over time, ravage occurs from "leakage," and one ages.

      With the immense stress now here and more coming very soon now, and the chaos coming to America that one has never seen before, the excessive stress will accelerate ROS damage faster. Just look at the various Presidents of the U.S. when they enter office; then, a few years later; when they leave. Old is the word! And, if you notice carefully when they speak after leaving office, or in a second term, they appear to have cognitive deficits in formulating their words or thoughts near the end of that second term. They do stumble through it, but the vim and vigor is gone. Their aggressive speech is gone...and their bodies are gone...soon for good.

      Peroxisomes are peroxide bodies, known as cytoplasmic organelles. They are involved in oxidative reactions that use molecular oxygen. These peroxide bodies are "a small organelle (a type of microbody) that is bounded by a single membrane and found in plant and animal cells. It contains enzymes that are involved in oxidation processes, some of which generate the highly toxic compound hydrogen peroxide (H2O2). Hence, peroxisomes are equipped with catalase, an enzyme that breaks down H2O2 into water and oxygen. Peroxisomes are the main site of fatty–acid oxidation in plant cells and also play a significant role in this regard in animal cells. They are responsible for neutralizing toxins absorbed from the blood, especially in the cells of the liver parenchyma and proximal convoluted tubule of the kidney" — Oxford Dictionary of Biology: New Edition.

      From this, one can see what fresh hell is caused to the liver and kidneys of the organism daily. Other cells of an organism are under attack as are these just enumerated.

      There are peroxisome proliferators such as various xenobiotics (drugs, medications, plasticizers, etc.). Peroxisome proliferation is associated with DNA damage in the cell.

      "Reactive oxygen species generated from cellular organelles (in particular the endoplasmic reticulum, peroxisomes and mitochondria) constitute a major source of oxygen radicals produced in cells. Peroxisomes are major sites of oxygen utilization where molecular oxygen is used to remove hydrogen from organic substrates. An end product of this reaction is hydrogen peroxide. Typically, catalase, which is present in the peroxisomes, reduces the hydrogen peroxide to water. Certain xenobiotics (peroxisome proliferators) are able to induce an increase in the number and size of peroxisomes in the cell.

      "When this occurs, enzymes responsible for beta–oxidation of fatty acids in peroxisomes are increased 20– to 30–fold while catalase activity is increased only two–fold. Thus, more hydrogen peroxide is produced than can be scavenged by the catalase. It has been suggested that hydrogen peroxide can in turn "leak" from these peroxisomes. This additional hydrogen causes an oxidative stress in the cell. The excess production of hydrogen peroxide in the cells has been demonstrated with a number of peroxisome proliferating compounds..." — Free Radical Toxicology, p. 379.

      In normal cellular metabolism, such as that found in cytochrome P–450 enzymes, reactive oxygen species may be generated from foreign substances. ROS is everywhere in the body and "leaks" from its protective compartments, causing damage. Obsolescence is built into the body.

      Drugs, medications, just staying alive, exercise, and practically anything that uses oxygen, generates ROS that eventually gets us. There are some things we can do to lessen its effects and excessive generation, such as reducing PUFAs, keeping lipid peroxidation down as much as possible, ingesting a sensible diet with reduced calories, using coconut and palm kernel oil, real beef fat, butter, lard, and tallow, among other things, but in the end those who survive will be those with superior biochemistries.

      We do not know who they are. Hence, it behooves one to follow the ideas given in this document and hope we improve our biochemistry, such that it will be ready for the tremendous onslaught it has been set up for from the total collapse of our economic system, the unbelievable confusion and chaos that is being generated. Then, we have, possibly, terrific forces coming from the stars.

    • Vitamins, Minerals & Enzymes Defenses:

      As discussed above, cells have a number of procedures or mechanisms to guard and protect themselves from reactive oxygen species. As given previously, the enzyme, superoxide dismutase (SOD), scavenges (removes) the free radical, superoxide. SOD is a free radical sink for the superoxide anion.

      "A radical, by definition, is an atom that has an unpaired electron in an outer orbital. It is highly reactive, and can initiate chain reactions by extracting an electron from a neighboring molecule to complete its own orbital. In contrast, the transition metals such as Fe (iron), Cu (copper), and Mo (molybdenum) are more stable and are not considered free radicals.

      "O2 is really a biradical; it has two unpaired electrons. Because the 2 electrons have parallel spins, they cannot form a thermodynamically stable pair, and reside in separate orbitals" — Basic Medical Biochemistry: A Clinical Approach.

      Glutathione peroxidase, formed from glutathione, selenium, and proteins, is important with catalase. These two enzymes are necessary for removing hydrogen peroxide and lipid peroxides.

      Other antioxidants or cell defenders against reactive oxygen species are vitamins C and E. Cells are also protected by compartmentalization of the mechanisms that generate highly reactive oxygen species. And herein lies a problem we spoke of earlier: If the compartment breaks down or is not repaired properly as one ages; or, due to dysfunction, disease, drugs, microbes, medications, stress, etc., there is an outpouring of ROS that destroys surrounding cell membranes, DNA and other organelles. This is oxidative stress:

      It tilts the "see–saw," ROS to Removal Capacity, in the down–direction toward the position where ROS sits. The up–direction of the see–saw is where cellular compartments are riding, including cellular enzymes, vitamins E and C, and other cell defenses, such as catalase. When ROS is produced faster than they are removed, the ratio of ROS to its Removal is high and Oxidative Stress is occurring.

      As these processes continue and repair is made, but always with diminishing effect, the organism ages and eventually dies. Obsolescence is built into organisms. You may slow it down with so–called "good nutrition" and ingesting "anti–aging" neutraceuticals, but this is dependent upon one's basic biochemistry: Survival of the Fittest. It is coming and you cannot avoid it. This involves how quickly one repairs, builds, attacks and destroys negatives in the body. It involves how quickly and efficiently one's chemistry sinks ROS. It involves how little one's physiology allows "leakage."

      And all this, coupled to the unbelievable stress we are going to enter into and be forced to endure creates more bond scission — the breaking of a chemical (electrical) bonds (connections) in a compound in which the fragments are unchanged free radicals, such that, if an outside force of enormous magnitude, as that coming from the stars, will cause more than free radicals to be formed, but continue beyond that, such that the electrical connections holding the atoms forming the cells, forming the tissues together, that makes liver, kidneys, muscles, etc., come apart, and do not reform, disintegration occurs. More on this shortly with proteins, DNA, etc.

      The antioxidant vitamins, vitamins E, C, and β–carotene are compartmentalized. Vitamins E and β–carotene are found in membranes as these vitamins are lipid soluble. Vitamin C, being water soluble, is present in the cell's cytosol, the fluid content of the cytoplasm outside of the membrane organelles.

    • More on Reactive Oxygen Species:

      • Its Mechanism of Formation:

        As was given in the chart on ROS above, there are a number of oxygen metabolites. The major ones produced when oxygen is reduced one electron at a time are the reactive oxygen species: Superoxide (O2), the hydroxyl free radical (OH.), and the form of oxygen that is partially reduced, hydrogen peroxide (H2O2).

        Basic Medical Biochemistry: A Clinical Approach writes:

        "The free radicals are capable of reacting indiscriminately with any molecules with which they come in contact, extracting electrons, and generating new free radicals in cytotoxic oxidative chain reactions. The hydroxyl radical is probably the most potent of the ROS (what your WebMasters call the 'Chess Knight' of free radicals), and the probable initiator of the chain reactions which form lipid peroxides (ROOH) and organic radicals. Hydrogen peroxide, although not actually a radical, is an oxidizing agent and, in the presence of Fe2+ (Iron (II)) or another transition metal, generates the hydroxyl radical by the Fenton reaction.

        "Because hydrogen peroxide is lipid soluble, it can create damage at localized Fe2+–containing membranes far from its site of formation."

        Now, think about all the people who are ingesting food–grade hydrogen peroxide. Natural food stores, nutritionists, dentists, physicians, and others tell them how great it is to kill various microbes—it is.

        But, consider this: They counter the fact that hydrogen peroxide is removed by catalase. It is also removed by glutathione peroxidase, which is never mentioned. The point is this. It "cured" this or that, yet, the question that begs answer is oxidative stress. No one ever mentions this, nor do they mention that it may have, indeed, stopped or put in remission someone's symptoms and pain and suffering; only later to cause all the dysfunctions and disease conditions, such as cancer and others, to surface later because of the enhanced ROS the ingesters of hydrogen peroxide have to deal with. Oxidative Stress gets them in the end...maybe sooner. And they never consider leakage! And everyone leaks, especially as we get older.

        Basic Medical Biochemistry continues:

        "The superoxide anion, which can be formed from free O2 by donation of an electron to another free radical, is highly reactive but has limited lipid solubility and cannot diffuse far. However, O2 can also generate the more reactive hydroxyl and hydroperoxy radicals by reaction with hydrogen peroxide in the Haber–Weiss reaction" — Basic Medical Biochemistry: A Clinical Approach, p 330.

        A major reason the ultraviolet radiation from the Sun is so damaging to skin is probably due to the formation of the hydroxyl radical. To help the internal mechanism (catalase) protect against this potent toxic chemical, one should consider ingesting carnosine. It will scavange the free hydroxyl radical (HO.).

        Ionizing radiation produces in the organism oxygen free radicals, reactive oxygen species, and this is out of balance with ROS in the affirmative to the cellular defenses, which are not able to quell ROS fast enough. Hence, we have oxidative stress occurring from radiation.

        On this matter of "leakage" again, intermediates of free radicals from enzymatic reactions from the enzyme active sites "leak" from their active sites and react with molecular oxygen or other compounds in the organism, forming reactive oxygen species. Additionally, ROS is formed in the cell continuously through regular metabolic pathways.

        The electron transport chain components may "leak" to oxygen some electrons, one at a time, forming O2. "HOCL, or hypochlorous acid, is the major reactive component of household bleach. In the human, it is formed by neutrophils and other granulomatous cells from H2O2 during the destruction of foreign organisms in a response called the respiratory burst."

        The respiratory burst, also known as a metabolic burst, is the process in which oxygen consumption may increase markedly (i.e., in a pulse of several minutes' duration) starting in seconds of stimulation; much of the oxygen may be used to form superoxide radicals, as in phagocytosis (process of engulfing microbes and destroying them) — Dictionary of Microbiology and Molecular Biology, Second Edition.

        The granulomatous cells are the eosinophils, neutrophils, and macrophages. These leucocytes of the white blood cell line are the second line of defense the non–specific resistance to any pathogen, not involving specific responses of the immune system, such as B cells and T cells. They are ever present to fight microbial or foreign body invasion of the organism — Microbiology: An Introduction, Sixth Edition.

        When phygocytosis occurs, the ingested bacterial cell is digested. But first, there is a rapid increase, as given above, in oxygen consumption (Respiratory Burst). This is used to oxidize NADPH, which is designed to form superoxide anions. The ingested pocket that has formed into a circular object containing the bacteria is known as a vacuole. The superoxide anions are shed into the vacuole and converted to hydrogen peroxide, assisting in destroying the imprisoned bacterial cell.

        Here's the difficulty: Excess neutrophils that are present at this time find irritated joints, joints that have nothing to do with the bacteria, are attracted there, and could release superoxide, generating more damage in the arthritic joint. Obsolescence is built into the organism.

        The superoxide is present in only tiny amounts, but it can generate a chain reaction that causes mega amounts of damage. This destruction, generated by superoxide anions, creates a chain of reactions that is self–perpetuating.

      • Summarizing ROS Generation Strategies:

        "O2 has the potential to be exceedingly dangerous in the body. During evolution, the switch from energy generation by anerobic metabolism to the use of oxygen as the electron sink was one of the most important events. The danger occurs when a single electron is acquired by the O2 molecule to give the superoxide anion, a reactive corrosive chemical agent,

        O2 + e O2 .

        "The unpaired electron acquires a partner by attacking a covalent bond of another molecule"— Biochemistry and Molecular Biology, Elliott & Elliott, Third Edition.

        The metabolic and physiologic pathway of oxygen as it is being reduced step–wise so that it does not cause spontaneous combustion of the human organism, oxygen on its way to form water, first gains one electron, forming the superoxide anion, as given immediately above, then.

        The superoxide anion must be scavenged quickly and this is done by superoxide dismutase, generating H2O2 (hydrogen peroxide) and water as follows:

        O2 .  → H2O2 + H2O

        Hydrogen peroxide is a potent oxidizing agent and is used to destroy microbials in the organism, and as a household disinfectant. The reaction proceeds as follows:

        The H2O2 + catalase (or glutathione peroxidase in the brain)  → H2O + O2

        The H2O2 generates the hydroxyl radical (HO.) in the presence of an iron (II) containing membrane or another transition metal by the Fenton reaction. Because H2O2 is lipid soluble, it can damage membranes far from its site of generation when Fe2+ (iron (II)) or other transition metals are present in distal membranes.


        However, leakage occurs of these ROS, including the hydroxyl free radical. And damage can occur outside of the compartment generating it; or, at distal (further downstream) areas of tissues of the organism if the hydrogen peroxide is not scavenged effectively. Vitamin C and Carnosine can scavenge the hydroxyl radical (HO.). Take plenty; get carnosine at natural food stores. Take them individually, not in a one–a–day brand of vitamins.


        The hydroxyl radical is formed from hydrogen peroxide (see above) and follows the following reaction in the presence of iron (II) membranes, or other transition metals at the membrane's surface to generate the hydroxyl radical:

        The H2O2 + electron (e and 1H+)  → H2O + OH (hydroxyl radical)


        Note 1:

        Reactive oxygen species can be developed by microbes, drugs, medications for heart and cancer patients, in addition to the normal pathways of One–Step electron transfers by enzymes in the electron transport chain, also known as cellular respiration. Obsolescence is truly built into the body. And...let us not forget, radiation.

        It is a big "electron knocker." When this occurs, an electron is knocked off or out of its orbit, you have a free radical formed (and a highly energetic free electron that can also cause problems) that can cause the same to happen to another; and, as this one is scavenged by vitamins C and E, the other one does the same to another and the process goes on unless terminated immediately. What we are describing is a Chain Reaction. It can be autooxidation, involving lipid peroxidation, and others. Mutations can and do occur in the mitochondria DNA, such that electron transport pathways are blocked, and this may cause formation of ROS.

        Note 2:

        Our own Star, the Sun, is due for a "Shaking" soon. Serious problems could erupt on Planet Earth. Read Here, then, come back to this spot and consider the following:

        "In the 1970s government statisticians calculated that if all electricity were cut off, 30 % of the population would be dead within a month. Within a year, 80 % would be dead. And that was back in the 1970s ... now it's worse!"– The McAlvaney Intelligence Advisor, August 1999.


        Solar Storm Striking Earth. This Coming Storm In 2012 Has The Potential To Cause Serious Problems On Planet Earth

        Disrupting Life...Causing Death

        [Solar Storm Striking Earth]


        If the oxygen did not ungergo the above one–step electron reduction pathway (or by another mechanism) and instead was going to water and zero wait state instantaneously, you would have spontaneous combustion and no humans would ever form, or if something causes this above step to move faster by reducing the spin restriction of oxygen to that of organic molecules, spontaneous combustion would occur.

        If the parallel spin of oxygen were to change to the antiparallel spin of organic molecules, or if organic molecules with their antiparallel spin were to change to that of oxygen (parallel spin), spontaneous combustion would also occur. As given before, the dense electromagnetic fields we are now moving into, and the enormous electric currents in space, can cause this to occur. People may suddenly disappear in a flash.

        The naive will say, "They're been raptured." But, how do they explain when other organic molecules do the same? This is all dependent upon the wave fronts coming. It may be in the form of an S–curve and "snake" its way over parts of the earth as the earth rotates, not touching other areas. We do not know.

        But this we do know: Life, as we have come know it, had to learn to use oxygen, such that it did not spontaneously combust and disappear in a flash. The earliest organisms on planet earth billions of years ago learned such an action by "evolutionary" experiments of trial and error, developing enzymes such as cytochrome c, overcoming spin restriction. And this was probably after overcoming parallel and antiparallel spins.

        It would be something like the Flash you see when you click Here, and possibly the peel–off of protein tissue, discussed later. But, only more awesome, if one does not disappear in the flash.

        Commentary A:

        Somewhere in this Universe...or even, if it exists, the MultiVerse, exist beings, perhaps, hundreds of thousands of years ahead of us. They possess a weapon, an Ultimate Weapon. The same Planet Earth will have in the future. When? We do not know. But, we will have it eventually.

        This weapon that exists is The Ultimate Weapon. It is the Parallel or Anti–parallel Weapon. It will also be known as The Spin Restriction Weapon. It is the ultimate energy weapon. Wherever you point it, setting it to parallel/anti–parallel/ or spin–restriction, depending upon what they are pointing the hand–held unit at, and depending upon what is being pointed at as being parallel or anti–parallel, engaging the trigger mechanism, the object pointed at, buildings, personnel, etc. will disappear in a brilliant flash...forever.

        These beings will have discovered how to overcome the Spin Restriction of electrons wherever it exists, without the use of much energy involved.

        Commentary B:

        As MS will burst upon the scene with a vengence, and as more women have MS than men, so it will be with osteoperosis. Let us explain:

        Fractures from osteoporosis are on the rise. However, the medical establishment in their journals speak about effective ways to treat osteoporosis, giving the idea that progress is being effected in the treatment for osteoporosis.

        In Dr. Ray Peat's Article, Bone Density: First Do No Harm, Dr. Peat writes:

        "The real situation is very different. Fractures resulting from osteoporosis are increasing and osteoporosis is affecting younger and younger people."

        From our own private practice we are seeing more and more "younger" women diagnosed with bone density problems. Estrogen had been, and still is, the mainstay for osteoporosis, with other drugs. They are proving not to be too safe and are often ineffective.

        Dr. Peat continues by writing:

        "Many women are told to stop taking a thyroid supplement when osteoporosis is diagnosed, but hypothyroidism often leads to hyperprolactinema (high prolactin) and hypercortisolemia (high cortisol), which are two of the most clearly established causes of osteoporosis.

        "Calcitonin, vitamin D–active metabolite, and estrogen–'HRT' treatments can cause respiratory alkalosis (relative hyperventilation) [19,24] and hypothyroidism produces a predisposition to hyperventilation. [25] Hyperventilation tends to cause calcium loss. In respiratory alkalolis, CO2 (and sometimes bicarbonate) are decreased, impairing calcium retention, and in 'metabolic alkalosis,' with increased bicarbonate, calcium is retained more efficiently and bone formation is stimulated, and its dissolution is suppressed."

        There are other drugs out there for osteoporosis, and dentists are wary of them. You can go into a dentist's office and a sign cautions you to inform your dentist if you are taking certain drugs for bone thinning. They can cause rotting of the jaw bone and the dentist does not want to drill into the area for certain dispositions of dental work and possibly run into a rotten jaw bone.

        This Web Site has cautioned many times that women do not get enough Complete high protein. We also caution against soy protein and soy products. It is an estrogen mimetic (exhibiting mimicry). And one of the causes of atrophy of tissue is estrogen. Estrogen also causes bone formation suppression. [1]

        In their private practice, your WebMasters recommend Whey or Milk & Egg protein, without adulterants. We also recommend "red meat," whole milk and eggs.

        Dr. Peat continues in the Bone Density article:

        "Other women are told to reduce their protein consumption, or to take fluoride or whatever drug has been most recently promoted. A protein deficiency is a clear cause of osteoporosis, and bone density corresponds to the amount of protein consumed. Milk protein, especially, protects against osteoporosis, independently of milk's other important nutrients. Too much fluoride clearly increases the risk of bone fractures, [26] and the side effects of other drugs haven't been properly studied in humans, while they often have dangerous effects in animals.

        "Calcium, magnesium, vitamin A, vitamin B6–, vitamin K, and vitamin D are important for the development and maintenance of bones. For example, a vitamin A deficiency limits the synthesis of progesterone and proteins. In calcium deficiency, parathyroid hormone is increased, and tends to cause the typical changes of aging, shifting calcium from hard tissues to soft, and decreasing the ration of extracellular to intracellular (excitatory) calcium.

        "Polyunsaturated fats are converted to prostaglandins (especially under the influence of estrogen), and several prostaglandins have toxic effects on bone. Those fats also suppress the formation thyroid hormone and progesterone. The increased use of the unsaturated oils has coincided with the increase of osteoporosis."

        Editor's Comment:

        The Killing Mechanism, most definitely, is up and running for Women! It is as if The Light Bearer himself, is getting even with women...because of The Woman!

        Continuing with Dr. Peat...

        "The oxidation of proteins caused by free radicals is increased with aging and by the use of unsaturated fats, and it contributes to tissue atrophy, including the age-related shrinkage of the bones. In animal studies, 'adequate' dietary protein, 13.8% of the diet (equivalent to about 80 grams per day for a person) is associated with more oxidative damage to tissue proteins than the very high protein diets, 25.7% or 51.3%, that would be equivalent to about 150 or 300 grams of protein daily for a person. [27] Yet, many physicians recommend a low protein diet to protect against osteoporosis.

        "Avoiding fluoridated water and the polyunsaturated oils, and drinking two quarts of milk daily (which will provide only 66 grams of protein) and using some other nutrient-rich foods such as eggs and fruits, are probably the basic things to protect the bones. For vitamins, especially K, occasional liver can be helpful. Meats, fruits, leaves, and coffee are rich in magnesium.

        "Some people have argued that the acidity of urine produced by eating meat causes calcium loss. However, a high protein diet also improves the absorption of calcium by the intestine. Another overlooked function of dietary protein is that it stimulates insulin secretion, and insulin is anabolic for bone. [28]

        "The same diet that protects against osteoporosis, i.e., plenty of protein and calcium, etc., also protects against kidney stones and other abnormal calcifications."

        Bone Density: First Do No Harm References.


        Presently, many are on low–sodium diets, often coupled with diuretics. This causes problems. In regard to the prolactin mentioned above, decreased sodium intake increases serotonin. The latter causes increased prolactin secretion. This increases sodium loss in the urine and presents with with decreased sodium in the blood. It's a "Catch–22" situation: The latter is equivalent to decreased sodium in the blood, and around and around it goes.

        Now, decreased sodium intake increases adrenalin and this causes many effects that are harmful, one being insomnia. This problem is especially prevalent in the elderly...but now, we're seeing it in young people on low–sodium diets. They often take diuretics because of bloat or water gain. The problem is compounded.

        Note:

        The activity of the Sympathetic Nervous System (SNS) increases as one ages. When sodium restriction is applied, often with diuretics, the problem is exacerbated. Sleep deprivation is one of the problems of aging, including increased activity of the SNS. I have found this also with law enforcement officers who want to shed weight: They go on low–sodium diets, and some include their wife's, girl friend's, etc. diuretics and complain about not sleeping well.

        The increased activity of the SNS contributes to the following:

        • Brain degenerative changes.

        • Capillary leakage.

        • Insulin resistence increases and this causes free fatty acids to be present in the bloodstream.

        Note:

        Blood vessel flexibility in the body is decreased with a low–salt diet, and there is increased activity of the SNS. This causes vascular stiffness, which generates hypertension, especially as one ages.

        Commentary C:

        You can undo a Superior Biochemistry! You may have been blessed with a robust genetic code and natural cellular defenses more superior to your neighbor. Your leakage may be far minimal than that of another human. Your ability to regenerate glutathione peroxidase and catalase may be superior to those of less robust biochemistry and repair, as well as scavenging free radicals or mopping them up quickly, making them null and void. This all can be undone, however, if you fail to keep up your vitamin, mineral, and complete high protein intake. Without this your system may falter.

        Overloading your system with toxic polyunsaturated fats (PUFAs), which omega–3s are counted amongst the other unsaturated fats, such as flax seed oil, canola oil, fish oils, etc., and high ingestion of chemical–laden fabricated foods, you may well demote a superior biochemistry to one that won't survive.

        By the same token, if you work at maintaining your vitamin, mineral and quality protein intake as described, and you avoid PUFAs and other toxins, you will hopefully succeed at transforming a not–so–naturally blessed biochemistry into one that survives.


      For Those Regular Readers of ChemBioUpdate

      It's Still Coming

      To See What Could Cause This...Click Here


      To Be Continued....


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      Times in America will change rather abruptly.
      Your WebMasters suggest you check your
      Medicine Supply/List
      .

      We Feel This Is Going To Be A Long, Hard Siege
      Get Prepared...Time Is Short Now...
      Other WebPages of Interest:

      Purifying Water ¦ When The Hell Breaks ¦ Gun Page

      Galactic Plane

      Soon..The Rocks Will Fall...See The Galactic Plane

      [When The Rocks Fall]
      The Impact and Its Consequences

      Ronking & Gronking In Distress
      Press Play To Start
      Mass Extinctions Occur Around This Time Of Passing Through The Galactic Plane
      The Earth Is Also Coming To The End Of An Age, As The Precession Ends


      The Rocks Are Coming

      [The Rocks Are Coming]


      A City Being Stoned

      [A City Being Stoned]


      It is Now time to start downsizing....do you really need three or four vehicles...Cable or Direct TV... etc.?
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      Join a number of fax networks to stay apprised of what is coming and when it comes; what is going down.
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      In An UpComing Issue:
      The Killing Mechanism: Section Three

      Something You Need To Know For What's Coming


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